基于TRIZ理论滤咀排列鼓工装夹具优化设计

针对滤咀排列鼓工装夹具所存在的制造难度大,精度难于保证,效率低的问题。利用TRIZ理论进行分析,根据技术矛盾解决方法并结合问题的实际情况,获得了具体可行的解决方案。经过实践证明,此设计方案是可行的、可靠的,大大缩短了夹具的加工周期,提高了生产效率,节约了成本。     

A Dual Inhibitor of DYRK1A and GSK3β for β-Cell Proliferation: Aminopyrazine Derivative GNF4877

Loss of β-cell mass and function can lead to insufficient insulin levels and ultimately to hyperglycemia and diabetes mellitus. The mainstream treatment approach involves regulation of insulin levels; however, approaches intended to increase β-cell mass are less developed. Promoting β-cell proliferation with low-molecular-weight inhibitors of dual-specificity tyrosine-regulated kinase 1A (DYRK1A) offers the potential to treat diabetes with oral therapies by restoring β-cell mass, insulin content and glycemic control. GNF4877, a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) was previously reported to induce primary human β-cell proliferation in vitro and in vivo. Herein, we describe the lead optimization that lead to the identification of GNF4877 from an aminopyrazine hit identified in a phenotypic high-throughput screening campaign measuring β-cell proliferation.     

Extensive evaluation and classification of low-cost dust sensors in laboratory using a newly developed test method

An extensive evaluation of low-cost dust sensors was performed using an exponentially decaying particle concentration. A total of 264 sensors including 27 sensors with light-emitting diodes (LEDs) and 237 sensors with laser lighting sources were tested. Those tested sensors were classified into 4 groups based on the deviation from the reference data obtained by a reference instrument. The response linearities of all the tested samples for PM₁, PM_2.5, and PM₁₀ were in excellent agreement with the reference instrument, except a few samples. For the measurements of PM₁ and PM_2.5, the lighting source, that is, LED or laser, did not show any significant difference in overall sensor performance. However, LED-based sensors did not perform well for PM₁₀ measurements. The 32, 24, and 16% of all the tested sensors for PM₁, PM_2.5, and PM₁₀ measurement, respectively, are in the category of Class 1 (reference instrument reading ± 20%) requirement. The performance of the low-cost dust sensors for PM₁₀ measurement was relatively less satisfactory.     

光伏废料制备Si3N4-SiC材料的抗氧化性和抗侵蚀性

将光伏废料经酸洗除杂后,与硅粉按85∶15的质量比配料,以聚乙二醇做结合剂,成型为10 mm×10 mm×20 mm的生坯后,在1380℃保温2 h氮化制成Si3N4-SiC材料,然后研究了该Si3N4-SiC材料的抗氧化性和抗侵蚀性。结果表明:1)制备的Si3N4-SiC材料在空气气氛中抗氧化性较好,主要是由于其氧化产物Si2N2O和SiO2填充气孔,促进烧结,提高了试样的致密度。2)在静态熔盐(Na3AlF6)中的抗侵蚀性能较好,主要是由于Na3AlF6渗入气孔中,使其显气孔率降低。3)在动态熔盐中的抗侵蚀性相对变差,主要是由于CO2气体的搅拌和对Si3N4、SiC的氧化二者共同作用的结果。     

On cutting temperatures in high and ultrahigh-speed machining

Since Dr. Carl Salomon proposed the well-known hypothesis on cutting temperatures in 1931, the debate on the hypothesis has never stopped. It shows that ev     

金沙江上游水电站应对白格堰塞湖灾害的措施及经验

2018年10月、11月,西藏自治区昌都市江达县白格村两次发生山体滑坡造成金沙江断流并形成白格堰塞湖,给金沙江上游沿岸人民生产生活设施造成巨大安全威胁和超过百亿元的经济损失。华电金沙江上游水电开发有限公司组织所属企业及参建单位快速应对,采取撤离避让、工程防护、人工干预、生产恢复,推动后续处置、风险评估等措施,最大限度减轻了对金沙江上游叶巴滩、拉哇、巴塘、苏洼龙等在建水电站的灾害损失和后续影响,为类似灾害的处置提供借鉴经验。     

煤矿薄煤层定向钻孔水害探查技术研究

从保德煤矿水文地质条件出发，研究了矿区奥灰水突水危险性，计算了8号煤层底板安全隔水层厚度和突水系数。采用薄煤层定向钻探工艺对保德煤矿81312工作面胶带运输巷道和81313工作面辅助运输巷道底板以下岩层及10号煤层进行水害及隐伏构造探查，探明了8号煤层底板岩层地质构造及富水性，形成了区域薄煤层定向钻孔水害探查方法。研究表明，利用定向钻孔的一孔多用功能超前预抽10号煤层瓦斯，可为矿区安全开采提供保障。